A multihit, multistage model of chemical carcinogenesis
نویسندگان
چکیده
منابع مشابه
A multihit, multistage model of chemical carcinogenesis.
Carcinogenesis involves the accumulation of genetic changes within a single cell. Tumor promotion functions in the initial clonal expansion of an initiated cell but is generally not considered to influence later stages. To investigate whether tumor promotion can influence later stages of carcinogenesis we developed a two-hit 7, 12-dimethylbenz[a]anthracene (D) protocol designed to enrich for ke...
متن کاملMultistage Evolutionary Model for Carcinogenesis Mutations
We developed a mathematical model for carcinogenesis mutations based on the reaction diffusion, logistic behavior, and interactions between normal, benign, and premalignant mutant cells. We adopted a deterministic view of the multistage evolution of the mutant cell to a tumor with a fast growth rate, and its progress to a malignant stage. In a simple case of this model, the interaction between ...
متن کاملCompensatory regeneration, mitogen-induced liver growth, and multistage chemical carcinogenesis.
Liver cell proliferation has often been implicated to play a major role during different steps of the carcinogenic process. Most of the experimental studies indicating a close association between cell proliferation and liver cancer development have made use of a compensatory type of proliferative stimulus. However, liver growth may also be caused by direct hyperplasia after administration of pr...
متن کاملMultistage models of carcinogenesis.
The simple multistage model of carcinogenesis is outlined. It provides a satisfactory explanation of the power law for the age incidence of many forms of epithelial carcinoma, for the effects in human populations of changing exposures to supposed carcinogenic agents, and for many of the observed effects of applied carcinogens in animal experiments. In particular, the evidence on the effects of ...
متن کاملMultistage models for carcinogenesis.
The multistage model is tested on several human and animal data sets. It fits in some cases but not in others. With human lung cancer data, there is a drop in risk for ex-smokers quite different from the predictions of the model. The results are not conclusive but are compatible with the view that the multistage model provides a family of curves that often fit cancer incidence data, but may not...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1999
ISSN: 1460-2180,0143-3334
DOI: 10.1093/carcin/20.9.1837